Date: September 28, 2022 03:23AM
"Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer.
The results indicated that caffeine treatment significantly suppressed GC cell growth and viability and induced apoptosis by activating the caspase-9/−3 pathway. Furthermore, the anticancer effects of caffeine appeared to be sustained, as the caspase-9/−3 pathway remained active following caffeine withdrawal. In conclusion, caffeine may function as a sustained anticancer agent by activating the caspase-9/−3 pathway, which indicates that it may be useful as a therapeutic candidate in gastric cancer."https://ar.iiarjournals.org/content/32/9/3643
"Caffeine inhibits DNA repair by inactivation of the cell cycle checkpoints, resulting in cancer cell death. Conversely, caffeine also independently inhibits the proliferation of, and induces apoptosis of tumour cells."https://www.jkms.org/pdf/10.3346/jkms.2002.17.5.674
"These results suggest that high-dose of caffeine induces
apoptosis in human neuroblastoma cells, probably by increasing the caspase-3 enzyme activity"https://www.researchgate.net/publication/24238371_Caffeine_Induces_Cell_Death_via_Activation_of_Apoptotic_Signal_and_Inactivation_of_Survival_Signal_in_Human_Osteoblasts