Posted by:
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Date: August 15, 2013 08:36AM
http://en.wikipedia.org/wiki/Protandim#CompositionProtandim consists mainly of a blend of 5 herbal ingredients (amounts per caplet listed in parentheses):
Milk thistle (Silybum marianum) extract (225 mg)
Bacopa (Bacopa monniera) extract (150 mg)
Ashwagandha (Withania somnifera) root (150 mg)
Green tea (Camellia sinensis) extract (75 mg)
Turmeric (Curcuma Ionga) extract (75 mg)
Additional ingredients include: calcium, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, modified cellulose, silica, and stearic acid.[citation needed]
Side effects
http://en.wikipedia.org/wiki/Protandim#Human_clinical_studiesTwo studies of Protandim have been conducted in human subjects. One of these studies, a non-randomized, non-controlled trial, reported that Protandim increased the levels of the antioxidant enzymes SOD and catalase in red blood cells while reducing TBAR levels in blood plasma.[7][24]
The second study, a double-blinded, randomized, placebo-controlled trial published by McCord and colleagues in 2012, examined the effect of Protandim on pulmonary oxidative stress and alveolar epithelial permeability in 30 recovering alcoholics.[25] Protandim (14 subjects at a dose of 1350 mg/day; double the daily dose recommended by the manufacturer) or placebo (in 16 subjects) were administered for 7 days. Relative to placebo-treatment, Protandim had no significant effects on alveolar epithelial permeability or on oxidative stress, epithelial growth factor, fibroblast growth factor, interleukin-1β, and interleukin-10 levels in bronchoalveolar lavage fluid. Treatment with placebo, however, produced a significant reduction in plasma levels of TBARS, a marker of oxidative stress (i.e., lipid peroxidation).