Date: September 19, 2021 12:54PM
Drinking sheep drench or eating horse paste will *not* cure you of COVID-19.https://www.merck.com/news/merck-statement-on-ivermectin-use-during-the-covid-19-pandemic/
Merck (NYSE: MRK), known as MSD outside the United States and Canada, today affirmed its position regarding use of ivermectin during the COVID-19 pandemic. Company scientists continue to carefully examine the findings of all available and emerging studies of ivermectin for the treatment of COVID-19 for evidence of efficacy and safety. It is important to note that, to-date, our analysis has identified:
No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
A concerning lack of safety data in the majority of studies.
We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.
Indications and Usage for STROMECTOL® (ivermectin)
Ivermectin is approved in the United States under the brand name STROMECTOL. STROMECTOL is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis and for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus.https://www.drugs.com/medical-answers/ivermectin-treat-covid-19-coronavirus-3535912/
Ivermectin is not FDA approved to treat COVID-19 patients. Ivermectin should only be used in patients for COVID-19 treatment in a research setting, as part of a clinical trial.
Ivermectin products that are approved for use in animals should NOT be taken by humans. Veterinary products are formulated to treat large animals and contain far higher levels of ivermectin than products approved for human use.
An in vitro trial has shown ivermectin reduces the number of cell-associated viral RNA by 99.8 % in 24 hours. An in vitro study is when they study cells in a laboratory and not in a living organism.
Clinical trials have been conducted on people to test how well ivermectin works against COVID-19. This is in vivo testing. Currently there is a low level of certainty whether ivermectin helps treat COVID-19 and more studies are needed.
Ivermectin tablets are currently a FDA approved medicine for treatment of intestinal parasitic worms, parasitic diseases, Strongyloides stercoralis and Onchocerca volvulus.
Invermectin has been established as safe for use in humans, but only at the recommended dosage level.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the virus that causes COVID-19 (coronavirus disease 2019)
What is Ivermectin?
Ivermectin is a medicine currently used to treat parasite infections such as intestinal worms, lice and mites.
Recently ivermectin has also been studied to treat a range of viruses.
How is Ivermectin thought to work on COVID-19?
For the SARS-CoV-2 virus to make you sick, it has to first infect your cells.
Then while inside the cell, the virus makes heaps of copies of itself, so it can spread around your body.
The virus also has ways of reducing the way your body fights the infection.
During the infection of the cell, some viral proteins go into the cell nucleus, and from here they can decrease the body’s ability to fight the virus, which means the infection can get worse.
To get into the nucleus the viral proteins need to bind a cargo transporter which lets them in.
Ivermectin can block the cargo transporter, so the viral proteins can’t get into the nucleus. This is how the scientists believe Ivermectin works against SARS-CoV-2 virus.
By taking Ivermectin, it means the body can fight the infection like normal, because its antiviral response hasn’t been reduced by the viral proteins.
Is Ivermectin an approved medicine by the FDA?
Ivermectin tablets (Stromectol) are an approved by the FDA for use in intestinal worms Strongyloides stercoralis and Onchocerca volvulus.
Ivermectin cream 1% (Soolantra) is FDA approved for rosacea.
Ivermectin is not FDA approved to treat COVID-19.
Ivermectin tablets are also used off-label for a number of other conditions.
Ivermectin intended for animal use should not be taken by humans.
STROMECTOL has no activity against adult Onchocerca volvulus parasites.