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Date: September 01, 2021 12:44AM
"Ivermectin binds to and destabilises the Impα/β1 heterodimer thereby preventing Impα/β1 from binding to the viral protein (bottom) and preventing it from entering the nucleus. This likely results in reduced inhibition of the antiviral responses, leading to a normal, more efficient antiviral response."
https://www.sciencedirect.com/science/article/pii/S0166354220302011There is in vitro evidence tht Ivermectin can decrease replication of Covid-19, but...
https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111678"An important controversial point to consider in any rationale is the 5 µM required concentration to reach the anti-SARS-CoV-2 action of ivermectin observed in vitro,17 which is much higher than 0.28 µM, the maximum reported plasma concentration achieved in vivo with a dose of approximately 1700 µg/kg (about nine times the FDA-approved dosification). In this sense, basic fundamentals for assessing ivermectin in COVID-19 at a clinical level appear to be insufficient. Among other reasons, we believe this might have led WHO to exclude ivermectin from its Solidarity Trial for repurposed drugs for COVID-19,12 which raises questions about the pertinence of conducting clinical studies on ivermectin."
And then:
"Concluding, research related to ivermectin in COVID-19 has serious methodological limitations resulting in very low certainty of the evidence, and continues to grow.37–39 The use of ivermectin, among others repurposed drugs for prophylaxis or treatment for COVID-19, should be done based on trustable evidence, without conflicts of interest, with proven safety and efficacy in patient-consented, ethically approved, randomised clinical trials."
Finally, the proper dose is not as simple as dividing the weight of a horse or cow by the weight of a human and decreasing the amount of the drug by that result.
Humans, cows, and horses may not have the same pharmacokinetics. The absorption, metabolism, and excretion may not be similar in humans and livestock which would affect the appropriate dosage.